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Glavni ciljevi i aktivnosti

- Primena biomaterijala prirodnog i veštačkog porekla u osteoreparaciji i regeneraciji kosti
- Uticaj mezenhimskih matičnih ćelija na osteogeni proces in vivo i in vitro
- Uticaj komponenti krvi na osteogeni proces in vivo i in vitro
- Priprema i kreiranje konstrukata od biomaterijala (ili 3D skafolda), ćelija i faktora rasta, za in vivo i in vitro pretklinička ispitivanja
- Procena ostegenenog procesa, osteoregeneracije i ostereparativnog procesa na različitim in vivo ektopičnim i ortopičnim modelima modelima korišćenjem oglednih životinja: miševa, pacova i kunića
- Konstrukcija in vivo modela regeneracije kostiju po principu biološke trijade: nosač + faktori rasta + ćelije sa primenom mineralnog matriksa kosti kao skafolda i nosača ćelija i faktora rasta, plazme obogaćene trombocitima kao inicijalnog izvora faktora rasta i mezenhimskih matičnih ćelija
- Primena matičnih ćelija ADMSCs koje su prethodno in vitro indukovane ka osteblastima ili endotelnim ćelijama za indukciju ektopičnog ostegenog procesa
- Procena stepena osteogenog procesa i vaskularizovanosti na modelu implantacija oglednim životinjama na osnovu ekspresije proteina i gena, histološke slike i histomorfometrijskih parametara.

 

 

 

 

 

 

 

Osoblje

Prof. dr Stevo Najman
As. Sanja Stojanović
Doc. dr Jelena Živković
As. dr Jelena Najdanović
Doc. dr Marija Vukelić-Nikolić
Prof. dr Zoran V. Golubović
Prof. dr Dragan Mihailović
Prof. dr Žarko Mitić
Prof. dr Žaklina Mijović
Prof. dr Sladjana Petrović, MD PhD
Doc. dr Milena Kostić

Istraživači sa Departmana za biologiju i ekologiju Prirodno-matematičkog fakulteta

Doc. dr Vladimir Cvetković
Doc. dr Jelena Vitorović
Milena Radenković

biografije osoblja


 

Ključne reči

- tkivno inženjerstvo, regenerativna medicina, bioinženjering, biotehnologija,
- biokompatibilnost, biomaterijal, mineralni matriks kosti, hidroksiapatit, nanomaterijali, bioaktivni biomaterijali,
- matične ćelije, mezenhimske matične ćelije, mezenhimske matične ćelije masnog tkiva (ADMSCs), stromalna vaskularna frakcija, masno tkivo, plazma obogaćena trombocitima,
- kost, osteogeneza, ektopična osteogeneza, osteoreparacija, osteoinduktivnost, osteokonduktivnost, vaskularizacija,
- defekt kosti, implant, implantacija, in vivo model, ogledne životinje,
- in vitro, ćelijska kultura, citotoksičnost, genotoksičnost, makrofagi,endotelske ćelije, osteogene ćelije,
- ekspresija gena

 

 

 

Ostvareni rezultati

Radovi u časopisima sa impakt faktorom

1. Najman Stevo, Cvetković Vladimir, Najdanović Jelena, Stojanović Sanja, Vukelić-Nikolić Marija, Vučković Ivica, Petrović Dragan. Ectopic osteogenic capacity of freshly isolated adipose-derived stromal vascular fraction cells supported with platelet-rich plasma: a simulation of intraoperative procedure. Journal of Cranio-Maxillofacial Surgery. Available online 24 August 2016. http://dx.doi.org/10.1016/j.jcms.2016.08.011
2. Takić Miladinova Dijana, Tomić Simonida, Stojanović Sanja, Najdanović Jelena, Filipović Jovanka, Trajanović Miroslav, Najman Stevo. Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid. Materials Research, Ahead of print Epub Aug 15, 2016. http://dx.doi.org/10.1590/1980-5373-MR-2016-0222
3. Đorđević Ljubiša, Najman Stevo, Vasiljević Perica, Miljković Miroslav, Ignjatović Nenad, Uskoković Dragan, Plavšić Milenko. Scanning Electron Microscopy Analysis of Changes of Hydroxiapatite/Poly-L-Lactide with Different Molecular Weight of PLLA After Intraperitoneal Implantation. Acta Veterinaria, 2016; 66(2): 234–244, DOI: 10.1515/acve-2016-0020
4. Najdanović Jelena, Cvetković Vladimir, Stojanović Sanja, Vukelić-Nikolić Marija, Čakić-Milošević Maja, Živković Jelena, Najman Stevo. Effects of bone tissue engineering triad components on vascularization process: comparative gene expression and histological evaluation in an ectopic bone-forming model. BIOTECHNOL BIOTEC EQ. Published online: 02 Aug 2016. doi: 10.1080/13102818.2016.1213662
5. Vuković Jovana, Babić Marija, Antić Katarina, Filipović Jovanka, Stojanović Sanja, Najman Stevo, Tomić Simonida. In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management. Materials Chemistry and Physics 2016; 175: 158–163.
6. Ajdukovic Zorica R, Mihajilov-Krstev Tatjana M, Ignjatovic Nenad L, Stojanovic Zoran S, Mladenovic-Antic Snezana B, Kocic Branislava D, Najman Stevo J, Petrovic Nenad D, Uskokovic Dragan P. In Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Properties. Journal of Nanoscience and Nanotechnology, 2016; 16(2): 1420-1428.
7. Ignjatović Nenad, Ajduković Zorica, Rajković Jelena, Najman Stevo, Mihailović Dragan, Uskoković Dragan. Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite. Journal of Bionic Engineering 2015; 12(4): 604–612. DOI: 10.1016/S1672-6529(14)6015.
8. Kostić Milena, Krunić Nebojša, Najman Stevo, Nikolić Ljubiša, Nikolić Vesna, Rajković Jelena, Petrović Milica, Igić Marko, Ignjatović Aleksandra. Artificial saliva effect on toxic substances release from acrylic resins. Vojnosanitetski pregled. Military-medical and pharmaceutical review 2015; 72(10): 899-905, DOI:10.2298/VSP140304070K
9. Barbeck Mike, Najman Stevo, Stojanović Sanja, Mitić Žarko, Živković Jelena, Choukroun Joseph, Kovačević Predrag, Sader Robert, Kirkpatrick C James, Ghanaati Shahram. Addition of blood to a phycogenic bone substitute leads to increased in vivo vascularization. Biomedical Materials 2015; 10(5). DOI:10.1088/1748-6041/10/5/055007
10. Cvetković Vladimir J., Najdanović Jelena G., Vukelić-Nikolić Marija Đ., Stojanović Sanja, Najman Stevo J. Osteogenic potential of in vitro osteo-induced adipose-derived mesenchymal stem cells combined with platelet-rich plasma in an ectopic model. International Orthopaedics. 2015; 39(11): 2173-2180. 10.1007/s00264-015-2929-x.
11. Najdanović Jelena, Cvetković Vladimir, Stojanović Sanja, Vukelić-Nikolić Marija, Stanisavljević Milica, Živković M. Jelena, Najman Stevo. The Influence of Adipose-Derived Stem Cells Induced into Endothelial Cells on Ectopic Vasculogenesis and Osteogenesis. Cel Mol Bioeng, 2015; 8:577-590. DOI: 10.1007/s12195-015-0403-x.
12. Rajković Jelena , Stojanović Sanja , Đorđević Ljubiša , Cvetković Tatjana , Najman Stevo. Locally applied cholecalciferol and alfacalcidol act differently on healing of femur defects filled with bone mineral matrix and platelet-rich plasma in ovariectomized rats. BIOTECHNOL BIOTEC EQ, 2015; 29( 5): 963-969, DOI:10.1080/13102818.2015.1055702
13. Savić VLj, Nikolić VD, Arsić IA, Stanojević LP, Najman SJ, Stojanović S, Mladenović-Ranisavljević II. Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root. Phytother Res. 2015; 29(8):1117-1122. DOI:10.1002/ptr.5356
14. Živković Jelena M, Najman Stevo J, Vukelić Marija Đ, Stojanović Sanja, Aleksić Milena V, Stanisavljević Milica N, Najdanović Jelena G. Osteogenic effect of inflammatory macrophages loaded onto mineral bone substitute in subcutaneous implant. Archives of Biological Sciences, 2015; 67(1): 173-186.
15. Mitic Zarko J, Najman Stevo J, Cakic Milorad D, Ajdukovic Zorica R, Ignjatovic Nenad L, Nikolic Ruzica S, Nikolic Goran M, Stojanovic Sanja T, Vukelic Marija Dj, Trajanovic Miroslav D. Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period. JOURNAL OF MOLECULAR STRUCTURE, 2014; 1074: 315-320.
16. Kostić Ivan, Mihailović Dragan, Najman Stevo, Stojanović Sanja, Kostić Milena. The rabbit gingival tissue response to retraction liquids and tetrahydrozoline. Vojnosanitetski Pregled 2014; 71 (1): 46-51.
17. Ignjatovic Nenad L, Ajdukovic Zorica R, Savic Vojin P, Najman Stevo J, Mihailovic Dragan S, Vasiljevic Perica J, Stojanovic Zoran, Uskokovic Vuk, Uskokovic Dragan P. Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2013; 24 (2): 343-354.
18. Cvetkovic VJ, Najman SJ, Rajkovic JS, Zabar ALj, Vasiljevic PJ, Djordjevic Lj,Trajanovic M. A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review. Veterinarni Medicina, 2013; 58 (7): 339–351.
19. Krunic Nebojsa, Kostic Milena, Najman Stevo J, Djindjic Natasa. Toxicity testing of prosthetic metacrylates. HEALTHMED, 2012; 6 (7): 2518-2524.
20. Vukelic Marija D, Mitic Zarko J, Miljkovic Miroslav M, Zivkovic Jelena M, Ignjatovic Nenad L, Uskokovic Dragan P, Zivanov-Curlis Jelena Z, Vasiljevic Perica J, Najman Stevo J. Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid. JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 2012; 10 (1): 43-48.
21. Krunic Nebojsa, Nikolic Ljubisa B, Kostic Milena, Najman Stevo J, Nikolic Vesna D, Najdanovic Jelena. In Vitro Examination of Oral Tissue Conditioners Potential Toxicity. HEMIJSKA INDUSTRIJA, 2011; 65 (6): 697-706.
22. Petrovic Dragan, Ajdukovic Zorica R, Petrovic Sladjana, Ignjatovic Nenad L, Najman Stevo J, Vuckovic Ivica. Semiquantitative radiological and clinical assessment of the restoration of alveolar bone defects treated with biphasic calcium phosphate/poly-dl-lactide-co glycolide composite. HEALTHMED, 2011; 5 (6): 2105-2114.
23. Kostic Milena S, Krunic Nebojsa, Nikolic Ljubisa B, Nikolic Vesna D, Najman Stevo J, Kostic Ivan, Rajkovic Jelena S, Manic Miodrag T, Petkovic Dusan. Influence of Residual Monomer Reduction on Acrylic Denture Base Resins Quality. HEMIJSKA INDUSTRIJA, 2011; 65 (2): 171-177.
24. Zivkovic P, Petrovic V, Najman SJ, Stefanovic VB. Stem Cell-Based Dental Tissue Engineering. SCI WORLD J 2010; 10:901-916.
25. Tomic SL, Dimitrijevic SI, Marinkovic AD, Najman S, Filipović JM. Synthesis and characterization of poly (2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels. Polymer Bulletin 2009; 63(6): 837-851.
26. Vasiljevic Perica J, Najman Stevo J, Djordjevic Ljubisa B, Savic Vojin P, Vukelic Marija D, Zivanov-Curlis Jelena Z, Ignjatovic Nenad L, Uskokovic Dragan P. Ectopic Osteogenesis And Hematopoiesis After Implantantion Of Bone Marrow Cells Seeded On HAp/PLLA Scaffold. Hemijska Industrija 2009; 63(4): 301-307.
27. Kostic Milena, Krunic Nebojsa, Nikolic Ljubisa, Nikolic Vesna, Najman Stevo, Kocic Jelena. Residual monomer content determination in some acrylic denture base materials and possibilities of its reduction. Vojnosanit Pregl 2009; 66(3): 223-7.
28. Janicijevic Jelena, Najman Stevo, Ignjatovic Nenad L, Savic Vojin, Kocic Jelena S,Vasiljevic Perica, Vukelic Marija, Uskokovic Dragan. Nanomaterial NP-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model. Hemijska Industrija 2008; 62(3): 205-210.
29. Kostic Milena, Najman Stevo, Kocic Jelena, Krunic Nebojsa, Ajdukovic Zorica, Petrovic Dimitrije, Andjelkovic Maja. Effect of denture base resin extracts on HeLa cells growth in vitro. Hemijska Industrija 2008; 62(3):217-222.
30. Kalicanin Biljana, Ajdukovic Zorica, Kostic Milena, Najman Stevo, Savic Vojin, Ignjatovic Nenad. The role of synthetic biomaterials in resorptive alveolar bone regeneration. Hemijska Industrija 2007; 61(2): 96-100.
31. Ajduković Z, Najman S, Đorđević Lj, Savić V, Mihailović D, Petrović D, Ignjatović N, Uskoković D. Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma. J Biomat Appl 2005; 20: 179-190.
32. Najman S, Savić V, Djordjević Lj, Ignjatović N, Uskoković D. Biological evaluation of hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterials with poly-L-lactide of different molecular weights intraperitoneally implanted into mice. Biomed Mater Eng 2004; 14 (1): 61-70.
33. Ignjatović, N, Savić V, Najman S, Plavsić M, Uskoković D. A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. Biomaterials 2001; 22 (6): 571-575.

Radovi u ostalim časopisima (delimičan spisak)

34. Jelena M. Živković, Marija Đ. Vukelić-Nikolić, Jelena G. Najdanović, Sanja Stojanović, Jelena S. Vitorović , Milena B. Radenković, Stevo J. Najman. Tkivno inženjerstvo kosti bazirano na kostnoj srži u krvnom ugrušku na mineralnom matriksu kao nosaču: eksperimentalna studija na subkutanom modelu miša. Acta Medica Medianae 2017; Vol.56(3): 5-11.
35. Kostić Milena, Krunić Nebojša, Najman Stevo, Rajković Jelena, Igić Marko, Petrović Milica, Janošević Predrag. Ispitivanje adherentnosti stomatoloških akrilatnih polimera in vivo. Acta stomatologica Naissi, 2014; 30(70): 1383-1392.
36. Kostić Milena, Najman Stevo, Najdanović Jelena, Krunić Nebojša, Kostić Ivan. Primena testa direktnog kontakta u ispitivanju citotoksičnosti stomatoprotetskih akrilata. Acta medica Medianae, 2012; 51 (1): 66-72.
37. Vukelić Marija, Mitić Žarko, Miljković Miroslav, Živković Jelena, Ignjatović Nenad, Uskoković Dragan, Vasiljević Perica, Petković Marija, Živanov-Čurlis Jelena, Najman Stevo. Interakcija biomaterijala na bazi kalcijum hidroksiapatita /poli-L-laktida i simulirane telesne tečnosti. Acta medica Medianae, 2011; 50 (4): 35-39.
38. Kostić Milena, Krunić Nebojša, Najman Stevo. Savremeni aspekt ispitivanja biokompatibilnosti materijala u stomatologiji. Acta stomatologica Naissi, 2010; 26 (62): 1007-1016.
39. Kostić Milena, Krunić Nebojša, Najman Stevo, Kocić Jelena, Veselinović Milena Promene na HeLa ćelijskoj kulturi u prisustvu akrilata za bazu proteze. Acta stomatologica Naissi, 2008; 24 (58): 793-800.
40. Milojević Mirjana, Najman Stevo, Tomić Simonida. Efekat hidrogelova na bazi 2-hidroksietil metakrilata na hemiluminescentnu aktivnost peritonealnih makrofaga pacova. Tehnika - Novi materijali, 2007; 16 (3): 5-8.
41. Ajduković Zorica R, Savić Vojin P, Najman Stevo J. Skening elektronsko-mikroskopska analiza alveolarne kosti izmenjene osteoporozom indukovanom kortikosteroidnim tretmanom. Acta stomatologica Naissi, 2007; 23 (56): 713-718.
42. Kostić M, Ajduković Z, Ignjatović N, Uskoković D, Savić V, Najman S, Kaličanin B, Mihailović D. Primena mikro i nano kompozita u osteoporozom izmenjenoj alveolarnoj kosti. Tehnika – Novi materijali, 2007; 16(2): 7-12.
43. Kalicanin B, Ajdukovic Z, Kostic M, Najman S, Savic V, Ignjatovic N. Uloga sintetickih biomaterijala u procesu regeneracije resorbovane alveolarne kosti. Hem Ind, 2007; 61(2):96-100.
44. Stanković M, Vasiljević P, Đorđević Lj, Najman S, Savić V. SEM analiza biokompozitnog materijala na bazi HAp/PLLA nakon subkutane implantacije uzoraka ispunjenih hematopoeznim ćelijama. Tehnika – Novi materijali, 2005; 14(1): 11-15.
45. Najman S, Đorđević Lj, Savić V, Ignjatović N, Vasiljević P, Miljković M, Uskoković D. Ćelijski odgovor na intraperitonealni implant kompozita PDMS/Hap. Acta medica Medianae, 2005; 44(3): 5-8.
46. Najman S, Vasiljević P, Đorđević Lj, Savić V. Characteristics of growth of mice bone marrow cultures in presence of biomaterials based on hydroxyapatite and poly-L-lactide. Acta Fac med Naiss, 2005; 22(3): 135-138.
47. Ajduković Z, Mihailović D, Najman S, Savić V, Aleksov Lj, Stanković S, Krunić N, Ristić K. Primena biomaterijala kod eksperimentalno indukovane osteoporoze alveolarne kosti. Stom Glas S (Serbian Dental J), 2003; 50: 13-17.
48. Najman S, Đorđević Lj, Savić V, Ignjatović N, Plavšić M, Uskoković D.
Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation. Facta Universitatis (Series Medicine and Biology) 2003; 10(3): 131-134.
49. Ajduković Z, Najman S, Nikolić R, Savić V, Uskoković D, Ignjatović N, Aleksov Lj. Atomska apsorpciona spektrofotometrijska analiza koštanog tkiva pacijenata sa dijagnostikovanom osteoporozom. Glasnik ADJ, 2003; 38:149-154.
50. Ajduković Z, Najman S, Savić V, Uskoković D, Ignjatović N. Rekonstrukcija defekata osteoporozom izmenjene alveolarne kosti (pilot studija). Bilten, Institut za nuklearne nauke Vinča, 2003; 1-4: 91-96.
51. Ajduković Z, Nikolić R, S Najman S, Mihailović D. Mineralne materije u koštanom tkivu i krvi ispitanica sa dijagnostikovanom osteoporozom. Acta stomatologica Naissi, 2002; 35: 39-40
52. Ajduković Z, Stanković D, Najman S, Mihailović D: Histopathologic analysis of experimentally induced osteoporosis. Balk J Stomatol, 2001; 5: 209-211.

Proceedings Papers

53. Mitić Ž, Stojanović S, Najman S, Cakić M, Ignjatović N, Uskoković D, Stolić A, Trajanović M. FTIR and SEM-EDX spectroscopic characterization of biomaterial calcium phosphate/poly-(dl-lactide-co-glycolide) under in vitro simulated physiological conditions. 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry “PHYSICAL CHEMISTRY 2014”, Belgrade, Serbia, 22-26 September, 2014, Proceedings-Volume II, p. 518-521.
54. Ž. Mitić, M. Vukelić, N. Ignjatović, D. Uskoković, P. Vasiljević, S. Najman, M. Trajanović, ATR-FTIR microspectroscopic characterization of nanomaterial calcium phosphate/poly-dl-lactide-co-glycolide in simulated body fluid, 11th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, Serbia, Conference Proceedings, H-12-P (2012), 456–458.
55. Ajdukovic Zorica R, Najman Stevo J, Savic Vojin P, Mihailovic Dragan S, Stankovic D, Aleksov Lj. SEM analysis of the alveolar bone osteoporosis of a rat. (Proceedings Paper) PROCEEDINGS OF THE 5TH MULTINATIONAL CONGRESS ON ELECTRON MICROSCOPY, (2001), vol. br. , str. 259-259

Radovi saopšteni na skupu međunarodnog značaja štampani u izvodu (delimičan spisak)

56. Najman S, Stojanović S, Vučković I, Petrović D, Najdanović J, Živković J, Vukelić M, Mitković M, Golubović Z, Mladenović D, Vasiljević P, Milovanović J, Trajanović M. Assisted regeneration of the human body - new strategies and technologies. 52nd Congress of Anthropological Society of Serbia, Novi Sad, June 5-8, 2013, Programme and Abstracts, page 74.
57. Aleksić M., Žabar A., Rajković J., Vasiljević P., Djordjević Lj., Mitić Ž., Najman S. Comparison of biocompatibility of three materials based on porouse apatite. Fifteenth Annual Conference YUCOMAT 2013, Herceg Novi, September 2-6, 2013, pp 139.
58. Ajduković Z, Ignjatović N, Petrović N, Rajković J, Kenić-Marinković D, Najman S, Uskoković D. NANOPARTICLES Ca/Co-HAp IN THE TREATMENT OF WEAKENED BONES JAW TEGMENTA. THE FIFTEENTH ANNUAL CONFERENCE YUCOMAT 2013, Herceg Novi, September 2-6, 2013, Programme and the book of Abstracts, p.147
59. Rajković J, Cvetković T, Najman S, Boričić M, Ajduković Z, Krstić V, Trajanović M. Biochemical parametars and CT scanner analysis as indicators of experimental model of postmenopusal osteoporosis induced by ovariectomy. 11th Symposium of the Flora of Southeastern Serbia and Neighbouring Regions, Vlasina Lake, September 13-16, 2013. Book of abstracts, p77-78.
60. Aleksić M, Rajković J, Vasiljević P, Đorđević Lj, Miljković M, Najman S, Jokanović V. Biocompatibility screening of biomaterial based on porous apatite with a film of alginate polymer. Serbian Ceramic Society Conference. Advanced ceramics and application II, Belgrade, Serbia, September 30.- October 1, 2013. Program and the Book of Abstracts p.53.
61. Najman S, Petrović D, Vučković I, Živković J, Stojanović S, Uskoković D. Osteogenic potential of freshly isolated cells of adipose-derived mesenchymal fraction applied with nanoparticles. Fifteenth Annual Conference of the Yugoslav Materials Research Society YUCOMAT, Herceg Novi, Montenegro, The Book of Abstracts, 2013, p.45
62. Najman S, Stojanović S, Najdanović J, Živković J, Petrović D, Vučković I, Cvetković V, Sekulović Lj, Tričković-Vukić D, Vukelić M, Vasiljević P, Trajanović M. Adipose derived mesenchymal stem cells as a model for study of osteoinductive activity of bone substituting biomaterials. Fourteenth annual conference YUCOMAT 2012, Herceg Novi, September 3-7, 2012. Book of Abstracts, page 126.
63. Najman S, Najdanović J, Petrović D, Vučković I, Živković J, Stojanović S, Cvetković V, Vukelić M, Sekulović Lj, Djindjić B. Osteo-regenerative potential of adipose tissue derived mesenchymal stem cells. XXXII Balkan Medical Week, Nis, Serbia, September 21-23, 2012. Book of Abstracts.
64. Ajduković Z, Ignjatović N, Petrović N, Najman S, Rajković J, Kenić Marinković D, Krstić V, Uskoković D. HEMOLYTIC ACTIVITY OF BIOACTIVE NANOCOMPOSITES. Joint event of the 11th Young Researchers’ Conference: Materials Science and Engineering, December 3 - 5, 2012, p49
65. Ajduković Z, Ignjatović N, Rajković J, Najman S, Mihailović D, Petrović N, Kenić Marinković D, Uskoković D. BIOACTIVE COMPOSITE MATERIALS IN REGENERATION OF THE RESORBED BONE OF ALVEOLAR RIDGES. Joint event of the 11th Young Researchers’ Conference: Materials Science and Engineering, December 3 – 5, 2012, p103
66. Ajduković Z, Ignjatović N, Savić V, Najman S, Mihailovic D, Rajković J, Petrović N, Uskoković D. HYDROXYAPATITE AND HYDROXYAPATITE SUBSTITUENTS IN STRENGTHENING OF THE JAW BONE TEGMENTA. FOURTEENTH ANNUAL CONFERENCE YUCOMAT 2012, Herceg Novi, September 3-7, 2012, Book of Abstracts, p121
67. Stojanović S, Najman S, Ajduković Z, Ignjatović N, Uskoković D. Comparative study of the effects of different nanomaterials of the viability of human osteoblast-like cells. Fourteenth Annual Conference YUCOMAT 2012 Herceg Novi, Montenegro, September 3-7, 2012; Book of Abstracts: P.S. E. 25.
68. Najman S, Stojanović S, Mitić Ž, Ajduković Z, Ignjatović N, Uskoković D. Examination of the influence of nanomaterials calcium phosphate/poly-(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of SAOS-2 cells. Joint event of the 11th Young Researchers Conference: Materials Science and Engineering and the 1st European Early Stage Researchers Conference on Hydrogen Storage, Belgrade, Serbia, December 3rd-5th, 2012; Book of Abstracts: Y 22.
69. Ajduković Z, Ignjatović N, Petrović N, Rajković J, Kenić Marinkovic D, Najman S, Uskoković D. Nanoparticles Ca/Co-HAp in the treatment of weakened bones jaw tegmenta. Fourteenth Annual Conference YUCOMAT 2013 Herceg Novi, Montenegro, September 2-6, 2013; Book of Abstracts: P.S. E. 22.
70. Ćirić M, Najman S, Bojanić V, Kaličanin B, Puškaš N, Velimirović D, Cekić S, Nešić M, Bojanic Z, Cvetković T, Sokolović D, Petrović S. Mineralization effect of simvastatin on tibia in neonatal treated rats with monosodium glutamate. Knjiga sažetaka, P146. 32nd Balkan Medical Week. September, 2012.
71. Mitić Ž, Vukelić M, Ignjatović N, Uskoković D, Vasiljević P, Najman S, Trajanović M. ATR-FTIR microspectroscopic characterization of nanomaterial calcium phosphate/poly-dl-lactide-co-glycolide in simulated body fluid. 11th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2011 Book of Abstracts 456-458.
72. Ajduković Z, Petrović MB, Milićević J, Djordjević N, Ignjatović N, Savić V, Najman S, Mihailović D, Vasiljević P, Uskoković D. Paramagnetic nanoparticles in the regeneration of the reduced alveolar bone density. Thirteenth Yugoslav Materials Research Society Conference, Herceg-Novi, 2011. Book of Abstracts.
73. Ajdukovic Z, Rajkovic J, Savic V, Najman S, Ignjatovic N, Uskokovic D. Application of nanoparticles Ca/Co-Hap in reparation of alveolar bone. 1st Conference of the Serbian Ceramic Society 1CSCS-2011, Belgrade, Serbia, March 17-18, 2011. Program and the Book of Abstracts p.73.
74. Stojanović S, Najman SJ, Najdanović J, Živković J, Najman SS, Ignjatović N, Uskoković D. Application of MTT viability test for biocompatibility examination of N-CP/DLPLG nanoparticules on cell cultures. Conference for Young Scientists, The Ninth Students Meeting, SM-2011 Processing and application of ceramics. Novi Sad, Serbia, November 16-18, 2011. Book of abstracts, page 66.
75. Najdanović J, Najman S, Zdravković J, Vasiljević P, Đordjević Lj, Čolović B, Jokanović V. The effects of the biomaterials based on hydroxilapatite on the viability of HeLa cells in culture. 13th Annual Conference YUCOMAT 2011, Herceg Novi, September 5-9, 2011. Abstact book - Additional abstracts.
76. Vukelić M, Najman S, Živković J, Stanisavljević M, Cvetković V, Najdanović J, Živanov-Čurlis J. The role of peripheral blood cells in the induction of ectopic osteogenesis. The effects of the biomaterials based on hydroxilapatite on the viability of HeLa cells in culture. 13th Annual Conference YUCOMAT 2011, Herceg Novi, September 5-9, 2011. Abstact book, page 174.
77. Najman S, Stojanović S, Najdanović J, Ignjatović N, Uskoković D. Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines. Tenth Young Researchers' Conference "Materials Science and Engineering", Belgrade, Serbia, December 21-23, 2011, Book of Abstracts, page 6.
78. Dodic N, Najdanovic J, Vukelic M, Zivkovic J, Stojanovic S, Stanisavljevic M, Stojiljkovic M, Najman S, Tomic S. The effect of hydrogel poly (ethylene glycol) dimethacrylates on the viability and proliferation. VIth International Pirogov Scientific Medical Conference of Students and Young Scientists, Moscow 24th March 2011, page 226.
79. Kostić M, Aleksov Lj, Kostić I, Krunić N, Najman S. Promene u ćeliskoj kulturi u prisustvu akrilata za izradu baza zubnih proteza. Simpozijum “Savremene tehnologije i privredni razvoj“ sa međunarodnim učešćem, oktobar 2011, Tehnološki fakultet Leskovac.
80. Krunić N, Kostić M, Nikolić lj, Nikolić V, Najman S, Rajković J. Reduction of potential denture base resins toxicity. Simpozijum “Savremene tehnologije i privredni razvoj“ sa međunarodnim učešćem, oktobar 2011, Tehnološki fakultet Leskovac
81. Vasiljević P, Najman S, Rajković J, Ajduković Z , Savić V, Ignjatović N, Uskoković D. IN VITRO INTERACTION BETWEEN BONE MARROW CELLS AND NANOMATERIALS CoHAp. Twelfth Annual Conference, YUCOMAT 2010. Herceg Novi, Montenegro, September 6-10, 2010. The Book of Abstracts, p. 166.
82. Najdanovic JG, Stojanovic ST, Zivkovic PS, Zivkovic JM, Vasiljevic PJ, Najman SJ. In vitro osteogenic differentiation and phenotypisation of mouse adipose tissue derived mesenchymal cells. IX International Congress of medical Sciences, Sofia, Bulgaria, Abstract Book, 2010, p.57
83. Kostić M, Krunić N, Najman S, Najdanović J, Aleksov Lj, Petrović D. The influence of the amount of residual monomer on the cytocompatibility of the acrylic resins for denture basis. 1st International Symposium on Contemporary Dentistry. June 3-4, 2010, Nis, Serbia, Abstract Book, str. 39-40.
84. Vukelić M, Mitić Ž, Miljković M, Živković J, Vasiljević P, Đorđević Lj, Živanov-Čurlis J, Ignjatović N, Uskoković D, Najman S. Scanning electron microscopy analysis of HAp/PLLA biocomposite after interaction with simulated body fluid. IX International Congress of Medical Sciences: The Book of Abstracts; 2010 May 13-16; Sofia, Bulgaria. p.58.
85. Kostić M, Krunić N, Najman S, Najdanović J, Aleksov Lj, Petrović D. Influence of the amount of residual monomer on the cytocompatibility of acrylic resins for denture basis. 1. Internacionalni Simpozijum o Savremenoj Stomatologiji- Hjuston u Nišu, Medicinski fakultet Niš, jun 2010.
86. Vukelić M, Mitić Ž, Janićijević J, Živanov-Čurlis J, Najman S. Fourier-transform IR spectroscopic study of biomaterials made of poly-L-lactide and poly(DL-lactide-co-glicolide). Sixth International Conference of the Chemical Societies of the South-Eastern European Countries, Sofia, Bulgaria, Book of Abstracts, 2008, p.444
87. Janićijević J, Najman S, Beljić N, Vukelić M, Ignjatović N, Uskoković D, Đorđević Lj, Vasiljević P. Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells. Ninth Annual Conference of the Yugoslav Materials Research Society YUCOMAT, Herceg Novi, Montenegro, The Book of Abstracts, 2007, p.181
88. Najman S, Milojević M, Tomić S, Vasiljević P. Effect of hydrogels based on 2-hydroxyethyl methacrylates to viability and oxidative ability of rat peritoneal macrophages. Ninth Yugoslav Materials Research Society Conference, Herceg-Novi, 2007. Book of Abstracts.
89. Milojević M., Najman S., Tomić S., Đorđević Lj. Effect of hydrogels based on 2-hydroxyethyl methacrylates to erythrocyte resistence to hemolysis. Ninth Annual Conference of the Yugoslav Materials Research Society, Herceg Novi, 2007. Book of Abstracts
90. Kaličanin B, Ajduković Z, Najman S, Nikolić R, Kostić M, Anđelković M. Study of the release of the heavy metals from various fixed dentures (appliances) into synthetic saliva, using electrochemical stripping analysis, Herceg Novi, YUCOMAT 2007; Book of Abstracts: P.S. E. 19.
91. Vasiljević P, Najman S, Đorđević Lj, Savić V. Effects of biocomposites HAp/PLLA on the bone marrow cells of Balb/c mice grown in vitro. Eighth Yugoslav Materials Research Society Conference, YUCOMAT 2006, Herceg Novi, Sep. 4-8, 2006; 143(P.S.E.8).
92. Ajdukovic Z, Ignjatović N, Petrović D, Savić V, Najman S, Petrović S, Živković R, Uskoković D: Evaluation of composite materials application in jaw bone recovery. Eighth Yugoslav Materials Research Society Conference, YUCOMAT 2006, Herceg Novi, Sep. 4-8, 2006; 144(P.S.E.9).
93. Najman S., Savić V., Lj. Đorđević., P. Vasiljević., I. Jovanović., N. Ignjatović., M. Plavšić., D. Uskoković. Osteogenic effects of added flavonoid extract in implants combined of Hap/PLLA and bone fragments. Eight Yugoslav Materials Research Society Conference, Herceg Novi, 2006. Book of Abstracts
94. Ajduković Z, Petrović D, Ignjatović N, Mihailović D, Savić V, Najman S, Petrović S, Uskoković D: Radiological and clinical assessment of the restoration of alveolar bone defects treated with biphasic calcium phosphate/poly-DL-lactide–co-clycolid composite. Seventh Yugoslav Materials Research Society Conference, YUCOMAT 2005, Herceg Novi, Sep. 12-16, 2005; 163(P.S.E.5).
95. Ajduković Z, Mihailović D, Savić V, Najman S, Đorđević Lj, Petrović D, Ignjatović N, Uskoković D: Substitution of osteoporotic alveolar bone with synthetic biomaterials. Sixth Yugoslav Materials Research Society Conference, YUCOMAT 2004, Herceg Novi, Sep. 13-17, 2005; 123(P.S.E.16).
96. Vasiljević P, Najman S, Djordjević Lj, Vukelić M, Savić V. In vitro interaction between bone marow cells and biocomposite HAp/PLLA. Seventh Yugoslav Materials Research Society Conference, Herceg Novi, 2005. Book of Abstracts.
97. Savić V, Stanković M, Vasiljević P, Djordjević Lj, Vukelić M, Miljković M, Najman S, Ignjatović N, Plavšić M, Uskoković D. SEM analysis bone marow cells in HAp/PLLA subcutaneous implants. Seventh Yugoslav Materials Research Society Conference, Herceg Novi, 2005. Book of Abstracts.
98. Đorđević Lj, Najman S, Miljković M, Savić V, Ignjatović N, Plavšić M, Uskoković D: SEM analysis of changes of different HAp/PLLA biocomposites after intraperiotoneal implantations. Sixth Yugoslav Materials Research Society Conference, YUCOMAT 2004, Herceg Novi, Sep. 13-17, 2004; 124(P.S.E.17).
99. Savić V, Mitković M, Najman S, Vukelić M, Đorđević Lj, Ajdukvić Z, Ignjatović N, Plavšić M, Uskoković D: Applicability of HAp/PLLA composite material in femur rapair. Sixth Yugoslav Materials Research Society Conference, YUCOMAT 2004, Herceg Novi, Sep. 13-17, 2004; 125(P.S.E.18).
100. Ajduković Z., Mihailović D., Savić V., Najman S., Đorđević Lj., Petrović D., Ignjatović N., Uskoković D. Substitution of osteoporotic alveolar bone with syntetic biomaterials. Sixth Yugoslav Materials Research Society Conference, Herceg Novi, 2004. Book of Abstracts
101. Vasiljević P., Najman S., Đorđević Lj., Savić V., Ignjatović N., Plavšić M. Uskoković D. Interaction of Hap/PLLA biocomposites with bone matrix after ectopic implantation. Sixth Yugoslav Materials Research Society Conference, Herceg Novi, 2004. Book of Abstracts
102. Ajduković Z, Savić V, Najman S, Aleksov Lj. Analiza alveolarne kosti nakon implantacije biomaterijala. XLII Kongres antropološkog društva Jugoslavije sa međunarodnim učešćem, 2003; 59.
103. Ajduković Z, Najman S, Savić V, Mihailović D, Stanković D, Aleksov Lj: SEM analysis of the alveolar bone osteoporosis of a rat. Proceedings of 5th Multinational Congress on Electron Microscopy, Lecce, 2001; 259-260.
104. Đorđević Lj, Najman S, Ignjatović N, Miljković M, Savić V, Uskoković D: SEM analysis of intraperitoneal implanted biocomposite of polysiloxane and hydroxyapatite. Fourth Yugoslav Materials Research Society Conference, YUCOMAT 2001, Herceg Novi, 2001; 95(P.S.E.6).
105. Savić V, Najman S, Đorđević Lj, Ignjatović N, Uskoković D: Changes in implants made of biocomposites HAp/PLLA and bone fragments after their subcutaneus implantation. Fourth Yugoslav Materials Research Society Conference, YUCOMAT 2001, Herceg Novi, 2001; 95(P.S.E.5).
106. Najman S., Savić V., Đorđević Lj., Ignjatović N., Uskoković D. Methods of evaluation of biological response to biocomposite implant based on hydroxyapatite. Fourth Yugoslav Materials Research Society Conference, Herceg-Novi, 2001. Book of Abstracts

Radovi saopšteni na skupu nacionalnog značaja štampani u izvodu (delimičan spisak)

107. Kostić I, Mihailović D, Najman S, Stojanović S, Kostić M. The rabbit gingival tissue response to retraction liquids and tetrahydrozoline. Tenth Young Researchers Conference – Materrials Science and Engineering, decembar 2011, SANU Beograd.
108. Najman S, Stojanović S, Najdanović J, Ignjatović N, Uskoković D. Assesment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines. Deseta konferencija mladih istraživača-nauka i inženjerstvo novih materijala, Beograd, Srbija, Zbornik abstrakata, 2011, str. 6. (M64)
109. Najman S, Rajković J, Kostić M, Krunić N, Savić V. SEM ANALYSIS OF THE SURFACE STRUCTURE OF ACRYLIC PROSTHETIC MATERIALS AFTER IMMERSION IN ARTIFICIAL SALIVA. Četvrti srpski kongres za mikroskopiju. 11-12. Oktobar 2010, Beograd, Srbija. Knjiga prosirenih apstrakata (str. 65-66.).
110. Kostić М, Najman S, Najdanović J, Krunić N, Kostić I, Petrović D. Ispitivanje citotoksičnosti oralno tkivnih kondicionera u uslovima in vitro. Osma konferencija mladih istraživača-nauka i inženjerstvo novih materijala, Beograd, Srbija, Zbornik abstrakata, 2009, str.21.
111. Vukelić MĐ, Mitić ŽJ, Miljković MS, Živković JM, Vasiljević PJ, Živanov-Čurlis JZ, Ignjatović NL, Uskoković DP, Najman SJ. Interakcija nanomaterijala kalcijum-fosfata/poli-dl-laktida-ko-glikolida (NCP/PLGA) i simulisane telesne tečnosti. Osma konferencija mladih istraživača-nauka i inženjerstvo novih materijala: Zbornik abstrakata; 2009 Decembar 21-23, Beograd, Srbija. p.20.
112. Veselinović M, Najdanović J, Kocić J, Stojanojević M, Vasiljević P, Janićijević J, Ignjatović N, Uskoković D, Najman S. Efekat nanomaterijala N-CP/DLPLG na rast HeLa ćelija u kulturi. Sedma konferencija mladih istraživača-nauka i inženjerstvo novih materijala, Beograd, Srbija, Zbornik abstrakata, 2008, str.22. (M64)
113. Veselinović M, Najdanović J, Kocić J, Stojanojević M, Vasiljević P, Janićijević J, Ignjatović N, Uskoković D, Najman S. Efekat nanomaterijala N-CP/DLPLG na rast HeLa ćelija u kulturi. Sedma konferencija mladih istraživača-nauka i inženjerstvo novih materijala, Beograd, Srbija, Zbornik abstrakata, 2008, str.22

Poglavlja u monografijama

114. Vasiljević PJ, Živković J, Vukelić-Nikolić M, Najman S. Determining the Biological Properties of Biomaterials In Vivo. In: Živić F, Affatato S, Trajanović M, Schnabelrauch M, Grujović N, Choy KL, editors. Biomaterials in clinical practice -Advances in Clinical Research and Medical Devices. Chapter in Book, Springer International Publishing; 2018. p. 477-499
115. Stojanović S, Mitić Ž, Miljković M, Rajković J, Trajanović M, Najman S. SEM-EDX Analysis of Bio-Oss® Granules After Incubation In Cell Culture Medium. Proceedings of the III Advanced Ceramics and Applications Conference, Chapter 18, W.E. Lee et al. (eds.) Atlantis Press and the author(s) 2016:259-264. doi: 10.2991/978-94-6239-157-4
116. Sanja Stojanović and Stevo Najman. Macrophages – The Key Actors in Adipose Tissue Remodeling and Dysfunction. In: Cell Biology - New Insights, Ed: Stevo Najman. InTech 2016: 187-196. DOI: 10.5772/62152
117. Ž. Mitić, Selected Instrumental Methods for Physicochemical and Spectroscopic Characterization of Different Biomaterials, In: Biomaterials in clinical practice - Advances in Clinical Research and Medical Devices, Editors: Fatima Zivic, Saverio Affatato, Miroslav Trajanovic, Matthias Schnabelrauch, Nenad Grujovic, Kwang-Leong Choy. Chapter in Book, pp. 573-584, 2017, Springer International Publishing AG, ISBN 978-3-319-68025-5; DOI: 10.1007/978-3-319-68025-5.
118. Najdanović J, Rajković J, Najman S. Bioactive Biomaterials: Potential for Application in Bone Regenerative Medicine. 2018. In: Biomaterials in clinical practice - Advances in Clinical Research and Medical Devices, Editors: Fatima Zivic, Saverio Affatato, Miroslav Trajanovic, Matthias Schnabelrauch, Nenad Grujovic, Kwang- Leong Choy. Chapter in Book, Springer International Publishing, 2018. DOI 10.1007/978-3-319-68025-5.
119. CVETKOVIĆ, Vladimir J.; MILADINOV, Dijana Takić; STOJANOVIĆ, Sanja. Genotoxicity and Mutagenicity Testing of Biomaterials. In: Biomaterials in Clinical Practice. Springer, Cham, 2018. p. 501-527.

Tehnička rešenja

1) Dušica Ilić, Vesna Nikolić, Ljubiša Nikolić, Mihajlo Stanković, Stevo Najman, Ljiljana Stanojević, Sanja Stojanović. Metoda određivanja citotoksičnog (vijabilnog) i citostatičnog (proliferativnog) dejstva alil-disulfida, alicina i proizvoda transformacije alicina. Ev. br. 06-2067/1, od 21.12.2011. NIO realizator: Tehnološki fakultet, Leskovac. Korisnik: Društvo za proizvodnju i trgovinu „DIAFARM“ DOO, Niš

Doktorske disertacije

Na bazi istraživanja ovog tima urađeno je i odbranjeno 10 doktorskih disertacija, a radi se na još 8 doktorskih disertacija.
- Milan Ćirić. Osteoreparativni potencijal simvastatina kod pacova sa gojaznošću izazvanom mononatrijum glutamatom. Niš: Univerzitet u Nišu, Medicinski fakultet, 2008. (Mentor: prof. dr Stevo Najman)
- Perica Vasiljević. Karakterizacija ćelija kostne srži regrutovanih za reparaciju kostnog tkiva potpomognutog tkivnim matricama. Niš: Univerzitet u Nišu, Prirodno-Matematički fakultet, 2010. (Mentor: prof. dr Stevo Najman)
- Ljubiša Đorđević. Induktivni potencijali implantirane demineralizovane kosti u lokalnom reparativnom rastu kosti na eksperimentalnom modelu. Niš: Univerzitet u Nišu, Prirodno-Matematički fakultet, 2011. (Mentor: prof. dr Stevo Najman)
- Marija Vukelić. Procena uloga kostne srži i komponenti krvi u ektopičnoj osteogenezi na modelu subkutane implantacije kod singenih Balb/c miševa. Beograd: Univerzitet u Beogradu, Biološki fakultet, 2011. (Mentor: prof. dr Stevo Najman)
- Jelena Živković. Modulatorni efekat makrofaga na osteogeni proces u ektopičnom in vivo modelu i u različitim uslovima in vitro. Beograd: Univerzitet u Beogradu, Biološki fakultet, 2014. (Mentor: prof. dr Stevo Najman)
- Jelena Rajković. Uporedna analiza efekata holekalciferola i alfakalcidola kao sastavni delovi implantata na proces zarastanja defekata u femuru ovariektomisanih pacova. Kragujevac: Univerzitet u Kragujevcu, 2015. (Mentor: prof. dr Stevo Najman)
- Vladimir Cvetković. Analiza ektopičnog osteogenog potencijala mezenhimskih matičnih ćelija belog masnog tkiva kod miša na osnovu relativne ekspresije gena markera osteogeneze. Beograd: Univerzitet u Beogradu, Biološki fakultet, 2016. (Mentor: prof. dr Stevo Najman)
- Jelena Najdanović. Uticaj mezenhimskih ćelija belog masnog tkiva miša, indukovanih in vitro ka endotelskim i osteogenim ćelijama, na vaskularizovanost ektopičnih osteogenih implanata. Beograd: Univerzitet u Beogradu, Biološki fakultet, 2016. (Mentor: prof. dr Stevo Najman)

 


 

 

 

 

Realizovani projekti

Istraživački tim koji se bavi regeneacijom kosti na pretkliničkim in vito i in vivo radio je i radi na realizaciji projekata Ministarstva sa resorom nauke, na internim projektima Medicinskog fakulteta Univerziteta u Nišu, kao i na istraživanjima koji se obavljaju u saradnji sa kolegama i istraživačkim institucijama u drugim centrima u Srbiji i u inostranstvu.

2011 – 2017 Virtuelni koštano zglobni sistem čoveka i njegova primena u pretkliničkoj i kliničkoj praksi (br. III41017); Potprojekat: Modeli osteoreparacije; Ministarstvo za prosvetu i nauku Republike Srbije

2017 – 2019 Karakterizacija biomaterijala u proceni biološki povoljnih interakcija sa ćelijama i tkivima (br. 15); Interni projekat Medicinskog fakulteta Univerziteta u Nišu

2006 – 2010 Regeneracija skeletnih tkiva potpomognuta biomaterijalima in vivo i in vitro studija (br. OI145072); Ministarstvo nauke i zaštitne životne sredine Republike Srbije

2006 – 2010 Biokompatibilnost i mogućnosti primene biomaterijala na bazi hidroksiapatita i biopolimera u tkivnoj reparaciji – eksperimentalna i klinička studija (br. OI145068); Ministarstvo nauke i zaštitne životne sredine Republike Srbije

2001 – 2005 Biokompatibilnost i primena kompozitnih materijala na bazi hidroksiapatita u osteo-rekonstruktivnoj hirurgiji - eksperimentalna i klinička studija (br. 1678); Ministarstva nauke i zaštite životne sredine Republike Srbije


 

 

 

 

Realizovani prototipovi

Istraživači iz tima su razvili metode za:
• ispitivanja biomaterijala i biološki aktivnih agenasa na različitim ćelijskim modelima in vitro,
• izolaciju ćelija iz humanih i animalnih tkiva,
• pripremu konstrukata od biomaterijala, ćelija i faktora rasta za ispitivanja na modelima biokompatibilnosti (citotoksičnosti, genotoksićnosti) in vitro i in vivo
• testove proliferacije, migracije ćelija, analizu ćelijskog ciklusa, apoptoze, fagocitoze,
• analizu ćelija u realnom vremenu,
• citohemijska i histohemijska bojenja,
• obradu i analizu tkiva histološkim, imunohistohemijskim i histomorfometrijskim metodama,


 

 

 

 

Realizovani patenti ili druga sredstva za valorizaciju istraživanja

Patenti:
1) G. Nikolić, M. Cakić, Ž. Mitić, Lj. Ilić, Sinteza, karakterizacija i farmakološka svojstva bioaktivnih kompleksa bakar(II)-jona sa pululanom i njegovim derivatima, Glasnik intelektualne svojine 2011/2, ISSN 1452-2144, Patent P–2008/0223, 16.05.2008.

Tehnička rešenja:
1) Dušica Ilić, Vesna Nikolić, Ljubiša Nikolić, Mihajlo Stanković, Stevo Najman, Ljiljana Stanojević, Sanja Stojanović. Metoda određivanja citotoksičnog (vijabilnog) i citostatičnog (proliferativnog) dejstva alil-disulfida, alicina i proizvoda transformacije alicina. Ev. br. 06-2067/1, od 21.12.2011. NIO realizator: Tehnološki fakultet, Leskovac. Korisnik: Društvo za proizvodnju i trgovinu „DIAFARM“ DOO, Niš

 

 

 



Istraživački resursi

Resursi i oprema na kojoj istraživački tim radi je u laboratorijama i odeljenijma Naučnoistraživačkog centra za biomedicinu Medicinskog fakulteta Univerzitata u Nišu.

http://www.medfak.ni.ac.rs/index.php/sr/f-ul/rg-niz-ci-f-ul/c-n-ri/c-n-r-z-bi-dicinu/168-centar-biomed
http://www.biomedicina.edu.rs/sr_RS/

 

 


 

 

 

Komercijalne usluge

Usluge su moguće kroz Naučnoistraživački centar za biomedicinu Medicinskog fakulteta Univerzitata u Nišu

 

Kontakt

Prof. dr Stevo Najman
Institut za biologiju i humanu genetiku
Naučnoistraživački centar za biomedicinu

Medicinski fakultet Univerziteta u Nišu
Bul. Dr Zorana Đinđića 81, 18000 Niš
Telefon: +381184226644, lokal 235 i 126 Faks: +381184238770

E-mail: stevo.najman@medfak.ni.ac.rs
stevo.najman@gmail.com
http://www.medfak.ni.ac.rs/index.php/sr/n-s-sss-si/140-dr-n-i-42
http://www.biomedicina.edu.rs/